i have a 1986 Toyota Escaper 21' class C RV with 22re, rear dually, auto trans. is it possible and if so how can i convert this to 4wd and lift 3" to 4" and convert to manual trans?  

Wow...The question is, is it worth the money to do it? Chances are, you'll probably end up spending more money doing the conversion than the vehicle is worth. If that's not a factor, it's probably possible. I think the RV-body Toyotas had 6-lug wheels. I know the 1-ton chassis (which they used for the RVs, I believe) have different hardware than the "normal" Toyota trucks.